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Dihydrofolate reductase I164L mutations in Plasmodium falciparum isolates: clinical outcome of 14 Kenyan adults infected with parasites harbouring the I164L …

Mary J Hamel, Amanda Poe, Peter Bloland, Andrea McCollum, Zhiyong Zhou, Ya Ping Shi, Peter Ouma, Kephas Otieno, John Vulule, Ananias Escalante, Venkatachalam Udhayakumar, Laurence Slutsker (Royal Society of Tropical Medicine and Hygiene, 2008)

Recently, Plasmodium falciparum bearing dihydrofolate reductase (DHFR) I164L was isolated from Africa. Quadruple mutations containing I164L confer high-level resistance to antifolate antimalarials. We prospectively measured ...

Intermittent Screening and Treatment or Intermittent Preventive Treatment With Dihydroartemisinin-Piperaquine Versus Intermittent Preventive Treatment With Sulfadoxine …

Meghna Desai, Julie Gutman, Anne L’lanziva, Kephas Otieno, Elizabeth Juma, Simon Kariuki, Peter Ouma, Vincent Were, Kayla Laserson, Abraham Katana, John Williamson, Feiko O ter Kuile (LWW, 2016)

In sub-Saharan Africa, there are >32 million pregnancies annually. As this is a malaria-endemic region, it is estimated approximately 12 million women who have live births (45% of live births) would be exposed to malaria ...

Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya

Helen M Nabwera, Dingmei Wang, Olukemi O Tongo, Pauline EA Andang’o, Isa Abdulkadir, Chinyere V Ezeaka, Beatrice N Ezenwa, Iretiola B Fajolu, Zainab O Imam, Martha K Mwangome, Dominic D Umoru, Abimbola E Akindolire, Walter Otieno, Grace M Nalwa, Alison W Talbert, Ismaela Abubakar, Nicholas D Embleton, Stephen J Allen, Neonatal Nutrition Network (NeoNuNet) (Public Library of Science, 2021)

Objective To describe the patient population, priority diseases and outcomes in newborns admitted <48 hours old to neonatal units in both Kenya and Nigeria. Study design In a network of seven secondary and tertiary ...

Clinical laboratory hematology reference values among infants aged 1month to 17 months in Kombewa Sub-County, Kisumu: A cross sectional study of rural population in Western Kenya

Jew Ochola Ouma, David H Mulama, Lucas Otieno, John Owuoth, Bernhards Ogutu, Janet Oyieko, Jackson C Korir, Peter Sifuna, Valentine Singoei, Victorine Owira, Stacey Maureen Okallo Gondii, Ben Andagalu, Walter Otieno (Public Library of Science, 2021)

There is an urgent need for reliable region-specific hematological reference values for clinical monitoring. Laboratory reference ranges are important for assessing study participant eligibility, toxicity grading and ...

Case report: Acute Kidney Injury, Liver impairment, Severe Anemia in a child with Malaria and Hyperparasitaemia

Harshil Gumasana, Walter Otieno (Global Journal of Medical and Clinical Case Report, 2021)

Severe Malaria is a medical emergency mainly because of its rapid progression to complications and death if not promptly and adequately treated. In 2018 WHO put the incidence of P. falciparum Malaria in the African region ...