Search
Now showing items 1-9 of 9
Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trial
(The American Society of Tropical Medicine and Hygiene, 2009)
Shortly after Kenya introduced artemether-lumefantrine (AL) for first-line treatment of uncomplicated
malaria, we conducted a pre-post cluster randomized controlled trial to assess the effect of providing malaria rapid ...
Antifolate Resistance in Plasmodium falciparum: Multiple Origins and Identification of Novel dhfr Alleles
(The University of Chicago Press, 2006)
BackgroundSulfadoxine-pyrimethamine has been widely used as first-line therapy for uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia and Africa suggest the triple-mutant dhfr genotype ...
Does cotrimoxazole prophylaxis for the prevention of HIV-associated opportunistic infections select for resistant pathogens in Kenyan adults?
(The American Society of Tropical Medicine and Hygiene, 2008)
We assessed the effect of daily cotrimoxazole, essential for HIV care, on development of antifolateresistant Plasmodium falciparum, naso-pharyngeal Streptococcus pneumoniae (pneumococcus), and commensal Escherichia coli. ...
Malaria and anaemia among pregnant women at first antenatal clinic visit in Kisumu, western Kenya
(Blackwell Publishing Ltd, 2007)
objective To determine the prevalence of malaria and anaemia among urban and peri-urban women
attending their first antenatal clinic (ANC) in an area of perennial malaria transmission.
methods Between November 2003 and ...
The effect of health care worker training on the use of intermittent preventive treatment for malaria in pregnancy in rural western Kenya
(Blackwell Publishing Ltd, 2007)
background In 1998, Kenya adopted intermittent preventive treatment (IPTp) with sulphadoxinepyrimethamine (SP) for malaria prevention during pregnancy. We conducted a survey in 2002 among
women who had recently delivered ...
Performance of malaria rapid diagnostic tests as part of routine malaria case management in Kenya
(The American Society of Tropical Medicine and Hygiene, 2009)
Data on malaria rapid diagnostic test (RDT) performance under routine program conditions are limited.
We assessed the attributes of RDTs performed by study and health facility (HF) staffs as part of routine malaria
case ...
Dihydrofolate reductase I164L mutations in Plasmodium falciparum isolates: clinical outcome of 14 Kenyan adults infected with parasites harbouring the I164L …
(Royal Society of Tropical Medicine and Hygiene, 2008)
Recently, Plasmodium falciparum bearing dihydrofolate reductase (DHFR) I164L was isolated from Africa. Quadruple mutations containing I164L confer high-level resistance to antifolate antimalarials. We prospectively measured ...
A randomized controlled trial of folate supplementation when treating malaria in pregnancy with sulfadoxine-pyrimethamine
(Public Library of Science, 2006)
Objectives: Sulfadoxine-pyrimethamine (SP) is an antimalarial drug that acts on the folate
metabolism of the malaria parasite. We investigated whether folate (FA) supplementation in a
high or a low dose affects the ...
Anna M van Eijk, Peter O Ouma, John Williamson, Feiko O Ter Kuile, Monica Parise, Kephas Otieno, Mary J Hamel, John G Ayisi, Simon Kariuki, Piet A Kager, Laurence Slutsker
(The University of Chicago Press, 2008)
Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by
the malaria parasite.We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to
assess the effect that folate ...