Mary J Hamel, Amanda Poe, Peter Bloland, Andrea McCollum, Zhiyong Zhou, Ya Ping Shi, Peter Ouma, Kephas Otieno, John Vulule, Ananias Escalante, Venkatachalam Udhayakumar, Laurence Slutsker (Royal Society of Tropical Medicine and Hygiene, 2008)
Recently, Plasmodium falciparum bearing dihydrofolate reductase (DHFR) I164L was isolated from Africa. Quadruple mutations containing I164L confer high-level resistance to antifolate antimalarials. We prospectively measured ...