Browsing School of Medicine by Title
Now showing items 446-465 of 550
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Rachs-1 system in rist stratification for congenital heart disease surgery outcome
(East African medical journal, 2008-05-28)Background: The Risk Adjustment in Congenital Heart Surgery (RACHS-1) system has been used as a benchmark to compare surgical results in developed countries. Its ability to stratify postoperative mortality risk has been ... -
A randomized controlled trial of folate supplementation when treating malaria in pregnancy with sulfadoxine-pyrimethamine
(Public Library of Science, 2006)Objectives: Sulfadoxine-pyrimethamine (SP) is an antimalarial drug that acts on the folate metabolism of the malaria parasite. We investigated whether folate (FA) supplementation in a high or a low dose affects the ... -
Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study
(Lippincott Williams & Wilkins, 2023)The genetics of rheumatic heart disease (RHDGen) Network was developed to assist the discovery and validation of genetic variations and biomarkers of risk for rheumatic heart disease (RHD) in continental Africans, as a ... -
Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†
(AHA, 2023)BACKGROUND: The genetics of rheumatic heart disease (RHDGen) Network was developed to assist the discovery and validation of genetic variations and biomarkers of risk for rheumatic heart disease (RHD) in continental ... -
Red blood cell immune complex binding capacity in children with sickle cell trait (HbAS) living in P. falciparum malaria holoendemic region of Western Kenya
(ARMY MEDICAL RESEARCH UNIT-KENYA APO NEW YORK 09675, 2013)Malaria infection leads to the formation of circulating immune complexes CICs which have been implicated in the pathogenesis of complicated malaria which includes severe malarial anemia. Children with sickle cell trait ... -
Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia
(The Feinstein Institute for Medical Research, 2008-03)Plasmodium falciparum malaria causes 1–2 million deaths per year. Most deaths occur as a result of complications such as severe anemia and cerebral malaria (CM)(coma). Red cells of children with severe malaria-associated ... -
Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality
(Pub Med Central, 2012-08)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
Reduced interferon (IFN)-α conditioned by IFNA2 (− 173) and IFNA8 (− 884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all
(Springer-Verlag, 2012-08-01)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
Reduced interferon (IFN)-α conditioned by IFNA2 (− 173) and IFNA8 (− 884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all …
(Springer-Verlag, 2012)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
Reduced Systemic Bicyclo-Prostaglandin-E2 and Cyclooxygenase-2 Gene Expression are Associated with Inefficient Erythropoiesis and Enhanced Uptake of Monocytic Hemozoin in Children with Severe Malarial Anemia
(Pub Med Central, 2012-08)In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children <48 mos. and manifests as severe malarial anemia [SMA; hemoglobin (Hb)<6.0 g/dL]. Induction of high levels of prostaglandin-E2 ... -
Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia
(Wiley Subscription Services, Inc., A Wiley Company, 2012)In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children aged <48 months and manifests as severe malarial anemia [SMA; hemoglobin (Hb) < 6.0 g/dL]. Induction of high levels of ... -
Reference intervals for some biochemical parameters in the aged Kenyan population.
(East African Medical Journal,, 1994)Serum levels for sodium, potassium, calcium, inorganic phosphate, urea nitrogen and creatinine were determined in 1101 male and 181 female patients aged 50 years and above. The determinations were carried out on the SMA ... -
Reflections on the first pan‐african conference on biochemistry and molecular biology
(Headington Hill Hall, 1997-07-01)After a couple of years of consultations with leading biochemists/molecular biologists in Africa and from abroad (playing advisory roles), the First Pan-African Conference on Biochemistry and Molecular Biology was ... -
Renal Biochemical Marker Changes in Restorative Activities of Curcuma longa on Sildenafil Induced Nephrotoxicity Among Male Albino Rats
(MJBAS, 2023-04-05)Nephrotoxicity is the rapid deterioration of kidney function due to altered histoarchitecture and drug clearance characterized by increased levels of renal biochemical markers. Sildenafil is among the drugs postulated to ... -
Renal gross morphological restorative effects of Curcuma longa on sildenafil induced nephrotoxicity among male albino rats.
(AJOL, 2023-08-17)Sildenafil is a phosphodiesterase inhibitor used in the management of erectile dysfunction and management of pulmonary hypertension. Curcuma longa is a traditional herbal plant that is commonly used as a diet in Africa and ... -
Reproductive toxicology: Edited by Raphael J Witorsch. pp 335. Raven Press, New York. 1995 ISBN 0‐7818‐0225‐9
(Headington Hill Hall, 1995-07-01)This volume incorporates material on stilbenes, bibenzyls, phenanthrene, their 9, 10- derivatives, and related plant products (similar in biosynthesis to fiavonoids), all derived from cinnamic acid and malonyl-CoA. The ... -
Research capacity. Enabling the genomic revolution in Africa.
(Science (New York, NY), 2014-06-01)Our understanding of genome biology, genomics, and disease, and even human history, has advanced tremendously with the completion of the Human Genome Project. Technological advances coupled with significant cost reductions ... -
Restorative effects of Azadicarachta indica on the kidney histomorphometry in cisplatintreated Wister albino rats
(AJOL, 2023-08-17)Cisplatin is used for treatment of soft tissue tumors and has been associated with nephrotoxicity. Azadirachta indica is a local herb that has been associated with attenuation and counteracting the nephrotoxic effects of ... -
The restorative effects of graded intensities of exercise training on the biochemical and nutritional status of obese induced male Wistar rats (Rattus novegicus)
(AJOL, 2023-05-16)The purpose of this study was to evaluate the specific effects of 12 weeks of intensive, graded intensities of exercise training on nutritional parameters and some plasma biochemical parameters in high-fat diet and sucrose ... -
A Review of 74 Patients with Newly Diagnosed Multiple Myeloma at A Tertiary Referral Hospital in Nairobi, Kenya
(Springer Paris, 2014)Introduction Multiple myeloma is a neoplastic disorder characterized by clonal proliferation of plasma cells. We aimed to carry out a retrospective audit to describe clinical and laboratory features of patients newly ...