Browsing Department of Public Health by Author "Were, T"
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Bacteremia in Kenyan children presenting with malaria
Were, T; Davenport, GC; Hittner, JB; Ouma, C; Vulule, JM; Ong'echa, JM; Perkins, DJ (American Society for Microbiology, 2011-02-01)Since the etiologies and clinical outcomes of bacteremia in children with Plasmodium falciparum infections, particularly in areas of holoendemic malaria transmission, are largely unexplored, blood cultures and comprehensive ... -
Clinical Predictors of Severe Malarial Anemia in a Holoendemic P. Falciparum Transmission Area
Hittner, James B; Davenport, GC; Ouma, C; Were, T; Obaro, S; Kaplan, S; Ong'echa, JM; Perkins, DJ; Novelli, EM (2005)Severe malarial anaemia (SMA) is a common complication of Plasmodium falciparum infections, resulting in mortality rates that may exceed 30% in paediatric populations residing in holoendemic transmission areas. One ... -
Functional Haplotypes of Fc Gamma (Fcy) Receptor (FcyRIIA and FcyRIIB) Predict Risk to Repeated Episodes of Severe Malarial Anaemia and Mortality in Kenyan...
Were, T; Ouma, Collins; Davenport, GC; Garcia, S; Kempaiah, P; Chaudhary, A; Anyona, SB; Raballah, E; Konah, SN (SN Konah, 2012)Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variations in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ... -
Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults
Were, T; Phawong, Chintana; Ouma, Collins; Tangteerawatana, Piyatida; Thongshoob, Jarinee; Mahakunkijcharoen, Yuvadee; Wattanasirichaigoon, Duangrurdee; Perkins, DJ; Khusmith, Srisin (Immunogenetics, 2012)Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40 subunit is associated with susceptibility to severe malaria in African populations. Since the role of genetic variation in conditioning ... -
Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria
Were, T; Otieno, Richard O; Ouma, Collins; Ong'echa, JM; Kelle, Christopher C; Waindi, Eliud N; Michaels, Marian G; Day, Richard D; Vulule, John M; Perkins, DJ (AIDS, 2005)Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria -
MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia
Were, T; Awandare, GA; Martinson, JJ; Ouma, C; Davenport, GC; Ong'echa, JM; Wang, W; L, Leng; RE, Ferrell,; R, Bucala,; DJ, Perkins (Journal of Infectious Diseases, 2012)Severe malarial anemia (SMA) resulting from Plasmodium falciparum infection is one of the leading causes of childhood mortality in sub-Saharan Africa. The innate immune mediator macrophage migration inhibitory factor ... -
Parasitemia, anemia, and malarial anemia in infants and young children in a rural holoendemic Plasmodium falciparum transmission area.
Were, T; Ong'echa, JM; Keller, CC; Ouma, C; Otieno, Richard O; Lewis, Z L; Ochie, D; Slingluff, JL; Mogere, S; Ogonji, GA; Orago, AS; Vulule, JM; Kaplan, SS; Day, RD; Perkins, DJ (American Journal of Tropical Medicine and Hygiene, 2005)Malarial anemia (MA) is a multifactorial disease for which the complex etiological basis is only partially defined. The association of clinical, nutritional, demographic, and socioeconomic factors with parasitemia, ... -
Polymorphic Variability in the 3'Untranslated Region (UTR) of IL12B is associated with Susceptibility to Severe Anaemia in Kenyan Children with Acute Plasmodium...
Raballah; Ong'echa, JM; Kempaiah, PM; Anyona, SB; Were, T; Davenport, GC; Konah, S; Vulule, JM; Ouma, C; Hittner, James B; Perkins, DJ (BioMed Central, 2005)Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children ... -
Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production
Otieno, Micheal F; Ouma, C; Davenport, GC; Awandare, GA; Keller, CC; Were, T; Vulule, JM; Martinson, J; Ong'echa, JM; Ferrell, RE; Perkins, DJ (PubMed, 2012)Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe ...