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Reduced Systemic Bicyclo-Prostaglandin-E2 and Cyclooxygenase-2 Gene Expression are Associated with Inefficient Erythropoiesis and Enhanced Uptake of Monocytic Hemozoin in Children with Severe Malarial Anemia
(Pub Med Central, 2012-08)
In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children <48 mos. and manifests as severe malarial anemia [SMA; hemoglobin (Hb)<6.0 g/dL]. Induction of high levels of prostaglandin-E2 ...
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.
(PubMed, 2012)
Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children
residing in regions where plasmodium falciparum transmission is holoendemic. Although
largely unexplored in children with SMA, ...
Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production
(PubMed, 2012)
Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to
Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in
conditioning the immunopathogenesis of severe ...