Browsing by Author "Ouma, Collins"
Now showing items 1-20 of 48
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(− 7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
Okumu, Wilson; Okeyo, Winnie A; Munde, Elly O; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (Bio Med Central, 2013)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Access to artemisinin-based combination therapy (ACT) and quinine in malaria holoendemic regions of western Kenya
Watsierah, Carren A; Ouma, Collins (BioMed Central, 2014-07-28)Artemisinin-based combination therapy (ACT) has been adopted as the most effective treatment against malaria in many endemic countries like Kenya while quinine has remained the second line. The objective of the current ... -
Assessment of community health volunteers’ knowledge on cervical cancer in Kadibo Division, Kisumu County: a cross sectional survey
Ochomo, Edwin O; Atieli, Harrysone; Gumo, Sussy; Ouma, Collins (BioMed Central, 2017-12)Globally, cervical cancer is the fourth most frequent cancer in women, with an estimated 530,000 new cases in 2012, representing 7.5% of all female cancer deaths. Of the estimated more than 270,000 deaths from cervical ... -
Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya
Munde, Elly O; Okeyo, Winnie A; Raballah, Evans; Anyona, Samuel B; Were, Tom; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BioMed Central, 2017-04-20)Background Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of ... -
Changes in antigen-specific cytokine and chemokine responses to Plasmodium falciparum antigens in a highland area of Kenya after a prolonged absence of malari...
Ochola, Lyticia A; Ayieko, Cyrus; Kisia, Lily; Ng'wena, G Magak; Shabani, Estela; Ouma, Collins; John, Chandy C (American Society for Microbiology, 2014-09-01)Individuals naturally exposed to Plasmodium falciparum lose clinical immunity after a prolonged lack of exposure. P. falciparum antigen-specific cytokine responses have been associated with protection from clinical ... -
Clinical chemistry profiles in injection heroin users from Coastal Region, Kenya
Were, Tom; Wesongah, Jesca O; Munde, Elly; Ouma, Collins; Kahiga, Titus M; Owuor, Francisca O; Kiarie, James N; Ahmed, Aabid A; Makokha, Ernest P; Budambula, Valentine (Biomed central, 2014-07-09)Background Although the co-burden of injection drug use and HIV is increasing in Africa, little is known about the laboratory markers of injection drug use and anti-retroviral treatment (ART) in Kenyan injection drug ... -
Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area.
Were; Novelli, Enrico M; Hittner, James B; Davenport, GC; Ouma, Collins; Obaro, Stephen; Kaplan, Sandra; Ong'echa, JM; Perkins, DJ (British Journal of Haematology, 2005)Severe malarial anaemia (SMA) is a common complication of Plasmodium falciparum infections, resulting in mortality rates that may exceed 30% in paediatric populations residing in holoendemic transmission areas. One ... -
Communicating African spirituality through ecology: Challenges and prospects for the 21st century
Gumo, Sussy; Gisege, Simon O; Raballah, Evans; Ouma, Collins (2012-06-19)This review was set in the context of African spirituality and ecology. Specifically, the review addressed issues of African spirituality and the environment from a Kenyan context. Through analyses on existing literature, ... -
Determinants of cervical screening services uptake among 18–49 year old women seeking services at the Jaramogi Oginga Odinga Teaching and Referral Hospital,...
Morema, Everlyne N; Atieli, Harrysone E; Onyango, Rosebella O; Omondi, Joyce H; Ouma, Collins (BioMed Central, 2014-08-06)Kenyan women aged≥ 15 years are at risk of developing cervical cancer. Currently, cervical cytology reduces cervical cancer incidence, since it allows for early diagnosis and treatment. Uptake of cervical screening ... -
THE EFFECT OF IN UTERO EXPOSURE THE PLASMODIUM FALCIPARUM MALARIA ON CORD BLOOD T REGULATORY CELLS THE CYTOKINES IN KENYAN I...
Ogolla, Sidney O; Daud, Ibrahim I; Asito, Stephen A; Coleman, Carie; Sumba, Peter O; Simbiri, Kenneth; Ouma, Collins; -Snyder, Robert Ploutz; Dent, Arlene; Rochford, Rosemary (AMER SOC TROP MED & HYGIENE, 2015-10-01)The effect of in utero exposure the plasmodium falciparum malaria on cord blood t regulatory cells the cytokines in Kenyan infants -
Effects of regional climate variability on the prevalence of diseases and their economic impacts on households in the Lake Victoria basin of Western Kenya
Ofulla, Ayub V; Gichere, Samuel K; Olado, Geoffrey O; Abuom, Paul O; Anyona, Douglas N; Maloba, Doreen; Matano, Ally-S; Gelder, Owuor; Dida, Gabriel O; Ouma, Collins; Owuor, Philip O; Amayi, Jairus B; Kanangire, Canisius K (Inderscience Publishers (IEL), 2016)Effects of regional climate variability on the prevalence of diseases and their economic impacts on households in the Lake Victoria basin of Western Kenya -
Efficacy of long lasting insecticidal nets compromised by insecticide resistance
Ochomo, Eric O; Bayoh, Nabie M; Walker, Edward D; Abongo, Bernard O; Ombok, Maurice O; Ouma, Collins; Githeko, Andrew K; Vulul, John; Yan, Guiyun; Gimnig, John E (Research Information Ltd, 2014-01-01)Malaria control is heavily reliant on the use of insecticides given that the two most common control tools, long lasting insecticidal nets (LLIN) and indoor residual sprays are both insecticide based. Of these, the ... -
Elly O. Munde, Winnie A. Okeyo, Samwel B. Anyona, Evans
Okumu, Wilson; Vulule, John; Ouma, Collins; Raballah, Stephen Konah; Ogonda, Lilian (2012)An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors (Fc ... -
Factors in the management of feeding in nursery school children as perceived by their mothers in rural Bondo County, Kenya
Were, Allan R; Kioli, Felix N; Onkware, Kennedy; Onyango, Elizabeth O; Gumo, Sussy; Ouma, Collins (BioMed Central, 2013-11-15)The effects of malnutrition on health status and survival of children has been the subject of extensive research for several decades. Malnutrition affects physical growth, cognitive development of children, morbidity ... -
Functional Haplotypes of Fc Gamma (Fcy) Receptor (FcyRIIA and FcyRIIB) Predict Risk to Repeated Episodes of Severe Malarial Anaemia and Mortality in Kenyan...
Were, T; Ouma, Collins; Davenport, GC; Garcia, S; Kempaiah, P; Chaudhary, A; Anyona, SB; Raballah, E; Konah, SN (SN Konah, 2012)Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variations in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ... -
Functional Haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children
Ouma, Collins; Davenport, Gregory C; Garcia, Steven; Kempaiah, Prakasha; Chaudhary, Ateefa; Were, Tom; Anyona, Samuel B; Raballah, Evans; Konah, Stephen N; Hittner, James B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J (Springer-Verlag, 2012-02-01)Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variations in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ... -
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.
T, Were,; CW, Gichuki; Ong'echa, JM; Ouma, Collins; Anyona, SB; Kempaiah, P; Raballah, E; Davenpor, GC; Konah, SN; Vulule, JM; Hittner, James B; Perkins, DJ (PubMed, 2012)Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ... -
Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area...
Munde, Elly O; Raballah, Evans; Okeyo, Winnie A; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BioMed Central, 2017-04-20)Background Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic ... -
Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults
Were, T; Phawong, Chintana; Ouma, Collins; Tangteerawatana, Piyatida; Thongshoob, Jarinee; Mahakunkijcharoen, Yuvadee; Wattanasirichaigoon, Duangrurdee; Perkins, DJ; Khusmith, Srisin (Immunogenetics, 2012)Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40 subunit is associated with susceptibility to severe malaria in African populations. Since the role of genetic variation in conditioning ... -
HAPLOTYPES WITHIN NFKBIA PROMOTER ARE ASSOCIATED WITH SEVERE MALARIAL ANEMIA AND CIRCULATING IL-10 AND IP-10 LEVELS IN CHILDREN...
Munde, Elly O; Achieng, Angela O; Kisia, Lily E; Karim, Zachery S; Raballah, Evans O; Kempaiah, Prakasha; Ong'echa, John M; Ouma, Collins; Perkins, Douglas J (AMER SOC TROP MED & HYGIENE, 2017-11-01)HAPLOTYPES WITHIN NFKBIA PROMOTER ARE ASSOCIATED WITH SEVERE MALARIAL ANEMIA AND CIRCULATING IL-10 AND IP-10 LEVELS IN CHILDREN WITH PLASMODIUM FALCIPARUM MALARIA